I would let your planned shooting needs choose the cartridge. High velocity will work against a barrel, but so does heat. It helps to time your shooting. Shooting thousands of rounds through a hot barrel will fry anything eventually. (Mistake I learned as a young man.) IMO, where the 22 250 and the 220 Swift come into there own is some extra range due to the bullet staying fast longer to reduce wind drift. Changing the barrel or replacing the rifle some day is the cost of doing business. If you are looking to shoot beyond 300 yards, personally, I would go with the 22 250 or 220 Swift.