In my experience, here's what I've found. The slower twists (1:48 in a Renegade I used to own) are best for PRB. Others here claim that if you use something like 1:66 or 1:70, you can really load a stiff charge with a PRB and not risk the patch skipping the rifling...leading to poor accuracy. However, you can use a PRB in a faster twist, but you just can't load 'em that stiff. Maybe 70 or 60 grs tops.
In my 1:28 Encore, I've had a modest degree of success using conicals with a 28 ga pink claybust shotgun wad with the petals cut off. However, my 1:38 Firehawk puts the Encore completely to shame when it comes to using conicals. The reverse can be said about my Encore's ability to shoot a sabot; it's awesome.
Now don't get me wrong, some people have had terrific success in shooting conicals out of fast twist barrels. Take the White rifle that's been discussed at length here. It's a fast twist rifle and it has worked wonderfully for many folks in shooting conicals...even sabots for that matter. The White rifle, though, has a much larger diameter those most other 50 cal rifles...in fact in
may have the largest diameter of any 50 cal rifle.
I suspect that the rate of twist in any ML is as important as its bore size. Since there are no firm standards in the ML industry for bore size as there are for centerfire calibers, it's almost impossible to make blanket statements about this twist being better than that twist for shooting really anything. You just have to try it and go with what works for
most people, because there's nothing that works for everyone.
However, based upon my reading the forum for about the last year or so, I would say that if you know you're gonna be shooting PRBs, get a 1:48, 1:66, 1:70 or something in that range so you can push those babies.
Geez, hope I didn't confuse you ...almost confused myself

Hopefully, Cayugad, Roundball, Sabotloader, or some of the really experienced folks with gun safes full of toys will chime in here.

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