Actually it has more to do with bullet design and shot placement depending one what you are hunting. All the velocity and energy in the world will do you no good if the bullet doesn't do what it is suposed to and you don't put it in the right spot.

You need to know what type of bullet to use on the game you are hunting and know the anotomy well enough to make a lethal shot. Varmint bullets and FMJ's really don't work that well on large game. One under penitrates and causes lots of damage and the other over penitrates transfering very little energy and creating a poor wound channel. Same thing works with small game or varmints. A big game controlled expansion bullet will zip right thru before the bullet has time to react and expand.

That's my opinion any way.

Paul