depending on the age of the pups you might beable to coax them out with a couple open cans of sardines, then catch them. with the pups gone momma yote will probably get the hint and move on. or you coud just pop off momma yote with that 300 mag. then nature will just take its toll on the pups they'll more then likely wind up lunch for a bobcat or just starve to death.

If you are able to catch the pups, you might call the humane society or animal control see if they'll take the pups and do what needs to be done with them relocate them if there is a wildlife relocation program in your area maybe more then likely they will be uthanized. Just dont be a sicko and post that you gas bombed them or blew them up with gasoline or any Theodore Kaczynski unabomber sicko cruelty to animal BS like that. which ever way you choose to get rid of them just be ethical.