RE: What is the best self defense ammo???
Laugh if you want,
I've always kept a loaded 22 auto loaded with hollow points at arms length from bed.A weapon my wife OR daughter can and would use and not be intimidated by recoil,blast etc..
I also have a SA Ruger 44 mag but its not loaded. I'll stick with the 22 and empty the clip into his pump house faster than he can hit the floor.