for a newcomer to big bores I'd suggest the .375 H&H as it can have some practical use in North America.....However you want something bigger and then I suggest either the 416 Rem Mag or the 416 Rigby.
go to
www.cz-usa.com and look at rifles and look over the cost of ammo carefully before you buy the gun.
The big bore crowd is pretty adamant about CRF and the CZ is all of that.
Either of the 416 rifles will handle anything on the planet as will the .375 H&H.