For Alaska I'd stay with the 250 gr grand slams, plenty of bullet for whatever you may come across. Talking to a gent at the range the other day who was shootinga 225 gr ballistic tips from his 35 whelen, when I asked about performance he said he used this load on a moose hunt. Recovered the bullet in the shoulder on the far side of a quartering away shot at 150 yds, recovered bullet weighed 165 gr. He was sure to point out that the wound channel was just utter devastation.