RE: What is in your powder container?
Every powder has a little unique quality.
If I want the smell & tradition, I'll seek Swiss BP.
If it want a clean bore &longer intervals before cleaning, I would seek Goex Pinnacle or American Pioneer.
If I want the most thumping power from a substitute, want small enough grains to reach under my sidelock nipples 100% of the time - including dirty bores& still want to go days before cleaning my ML, I reach for 777.
For the past three years, I've used 777 exclusively. It serves my entire variety of MLs.... ie....(1) powder - (1) grain FFF... for all my 45-58 caliber MLs
Noticing that you shoot a 54 with a heavier conical most times, I would suggest you narrow the playing field to Swiss, Goex, Pyrodex or 777.
Just my opinion on how I think some powder react to heavier bullets, heavier powder charges & bigger calibers. There may be an occasion when a powder like APP & some othersworks well with heavy bullet/heavy powder/big calibers..... but it's of my opinion that the success rate at 100 yards & beyond is of the minority nature.
There are exceptions to almost everything on this planet. Someone like myself - an every month shooter who likes to tinker for the past 10 years or-so has his own opinion after testing most-all powders on the market with various MLs, bullets & powder charges.