I also want to know "best in what way"????
Anyway, i have several 22's and to be honest i wouldn't pick the 10/22 because it feels like a "beached whale" in your hands when you carry it.
The 22 i like the best is the Remington 541-S. (mines left hand and in a sporter walnut stock) These rifles are amazeingly accurate and a joy to carry in the field.
Drilling Man