rick,

After 300 yards the 165 grain bullet will give you a flater trajectory than the 150 grain bullet. I have found almost all manuals hold pressure levels below 50,000 psi for the '06.There are good reasons for this that I won't go into here. But I see no problem, if you're using a rifle made after WWll, not to load the '06 to the same pressures as the .270 Win. The Hodgdon # 27 manual list these loads for H-4350, 150 grain bullet: 56.0 grains at 37,000 CUP for 2757 fps. Max Suggested load is: 62.0 grains at 48,400CUP for 3068 fps. I'm here to tell you that is a warm load and should NOT be used unless worked up to from below. For the 165 grain bullets the min.=53.0 grains at 34,000CUP for 2678fps, and max is 59.0 for 49,400CUPat 2938fps. Since Hodgdon used a 24 inch barrel to work up their loads, I usually stop my test loads one grain over book loads that used 24" or longer barrels to establish their loads since my rifle barrel is only 22".Don't do this if your rifle is the same length used by the publisher. I finally settled with 59.5 grains for the 165 grain, group of five shotsmeasured .247", velocity is 2830 fps with an extreme spread of 11.0 fps and a standard deviation of 5.1 fps. The bullet was the Sierra 165 grain hollow point boattail. Kills oryx real deal, real quick. Sorry I can't give you more infe on the 150 gr, I just haven't been able to finish all the test I want to run on it. I've also switched to the Nosler accubond so it may be awhile.

I think it's important that you let your rifle tell you what your load should be. If you listen to her, she'll tell you loud and clear what she likes. Then you have to decide if the results are what you like.