I would go with the 7mm-08 because with the 280 you will kill any deer out there but you are limited to what you can drop with it. The 7mm-08 on the other hand is a .308 cal cut down to a 7mm bullet, so you will get the power of a 308 pushing on as lighter 7mm bullet wich means more fps equals more ke equals further shots equals better knock down. They both are good guns so its totally up to you but I say 7mm-08