I think it really does come down to you, your gun & practice. When I first got my inline several years ago, I too was confused. I just decided to buy some different weights, powder, etc and play. I ended up with the Hornady 44 cal 240 XTP Sabots with 100 gr pyrodex pellets (2 x 50). They shoot nice groups at 100 and have performed flawlessly in the field for me. I have now taken 6 animals with this setup and couldn't be more pleased with the results. Like anything else ask 10 people your sure to get 6 different answers.

I personally haven't had any problems with sabot foulings, at the range I do barrel swab after each shot on most occasions. In the field I have never needed anything more than the initial shot.

Good luck and boy is it fun!!!!!!!