RE: What is good range for sighting in 12guage/.22-250
I know exactly what your problem is. You are shooting a Mathews bow which is only good out to about 10 yards. Now if you shot a BowTech you would notice even your shotgun and rifle groups improve.<img src=icon_smile_big.gif border=0 align=middle>
Seriously though, shooting a firearm at longer ranges will invoke Muurphy's law. What are you shooting, what ammo, how, etc? If we know more about your setup we might be able to help you figure it out.