Well, I am going to go against the grain somewhat here.

IMO if we are strictly talking about deer it depends on exactly what you are shooting.

Certain set up I wojuld most definetly stay away from the shoulder and leg bone. Such as my sons set up. He is only drawing 45 pounds with a 25" draw and shooting a relatively light arrow. Rib cage and broadside or quarting away only with him.

Other set ups I would have absolutely no problem shooting down through the shoulder or leg bone if I needed to. I personally shoot a 500 grain arrow and generate 80+ foot pounds of KE. With this set up I have no problem at all getting through the vitals after going through the shoulder blade or leg bone, or even through both legs, of a deer.