Did she have any fawns with her? I have heard from biologist that bucks will often prefer to breed smaller & younger does, not sure how true it is but if you have 200lb bucks on your land and a 200lb doe...with no fawns maybe their is some merit. Harvesting her would than be a good idea, if she ain't being breed than what use does she really have for your buck population or deer in general. QDM requires does to be limited to keep ratios in check, so harvesting does will always bring advantages to the area (as long as over harvesting doesn't happen). I personally don't shoot does with fawns, so that would be my only deterent, besides limit obviously. I say if she has fawns let her pass on her genes and wits, keep her around and take out another doe instead.