I use the 22lr all the time for foxand never had one run off. Farthest shot was 125yd with no wind.He only ran 25 yd before rolling with alung shot. I use american eagle 38 gr. hollow points.These rounds shoot great out of my gun. I shoot almost a brick a week at targets, ground squirrels, rockchucks and other things from 25-150yd so Iknow were to shoot. The key isknowing how your gun shoots and shot placment.