I had heard of firing a 44 special in a 410 but not a 45 Colt. I would hope the bore would be big enough. Buffalo Bore sells 45 Colt in heavier loadings. I could not quite tell from the original post whether the barrel is rifled or smooth. The logic I had heard behind shooting a pistol cartridge in the 410 was for protection against larger critters at close range. Like a slug.