I have one with 50 cal barrel,and a 25/06 barrel and everytime I change I have to reset the scope,both barrels have their own scope on them.I have added a oversize pin and tried indexing the pin but doesn't help.
Below is a shot group before and after changeing the barrel. Both are very acurate after getting them back to zero.
When I got the 25/06 barrel a shooting buddie and I shot six three shot groups @300 yds that measure one inch or less.But still every time I change the barrel the poi changes .
Before:

After changing barrels: