Actually this is what you asked.
I am wanting to buy a good 1000 yrd gun for varmints and maybe some big game. What I am wanting to know is which caliber would be better and i am going to put a leupold tactical scope. Or maybe a 325 WSM.
You clearly stated that you wanted a gun that was capeable of shooting varmints
and big game at 1000 yards. You made no mention of limiting shots on big game animals to 500 yards or less.
Another point..... By you meerly asking this question indicates to everyone here that you have never attemped shots at 1000 yards on paper, much less big game animals, and this would be a new challenge for you so we are going to give you advice based on that.
So don't get you panties all bunched up because people gave their opinions about atempting shots on live big game animals at 1000 yards. You got exactly the answers that you asked for.
Like I said earlier you are going to need some fairly specialized equipment to be effective at hiting targets the size of ground hogs at 1000 yards. If you want to play you gotta pay.