Most inline rifles seem to shoot the .50 caliber 250 grain Shockwaves real well. I shoot the 250 & 200 grain. Originally I shot the 300 grains and they all shot good, but the 250 grain were the bullet of choice.

Start them out with 100 grains and if your rifle allows it, push them a little harder and see what happens if you like. 100 grains and that bullet is plenty of medicine for what you need to cure most critters.