I just feel like adding a couple kinks in the equation,just for fun.
When dealing with MOST 1 cams the string will run at an extreme angle so leveling off the string will have you canting the bow so you would be better off,imo to set the 2nd axis off the sight bar.The best way is to do it at full draw but this is hard for most to accomplish without a machine to hold the bow at draw so at rest is usually good enough for most.
3rd axis is very beneficial for those that shoot from a deerstand as others have mentioned but what most have not mentioned isfourth axis and this one causes MUCH controversy on whether it is needed.It isneeded in target archery at extreme distancesbecause the bar usually doesn't run square with the riser and if your 3rd is set offthe bar,then it will not be accurate when mounted on the bow.Fourth axis gets the sight pins AND sight barsquare with the arrow and will allow the 3rd to be accurate.
Now that we are all confused,I will back outnow.[8D]