Any time you change any part of your loading or shooting procedure, there is a chance that it can effect the accuracy of the projectile. It might be to only a short degree, but it can. I suggest find a primer that works for you and your rifle, and is in your price range and stick with it. I for instance really like the new Remington Kleenbore Primers because I shoot loose powder 99% of the time and the cooler primer seems to be just the ticket. If I shoot pellets I then use Winchester W209 primers. They have just a little more fire and seem to make the pellets ignite andbehave better. Therefore they effect accuracy.