There was a gentleman shooting at our range that was using large rifle primers in a home made set up. He said he tried the small rifle primer set up and had misfires while hunting.
The way he rigged it up was with a brass tube. He said he turned the tube on a lathe so the frount was thin like a shell and sealed and the back fit the primer,he shot for a couple hours and never seamed to have a problem,he switched the tubes in and out just like you would a shell case.
If any one knows any commercial set up where they have some thing that uses large rifle primers and seals up like that to keep the breach area clean I would appreciate them leting me know it looked like the best answer to me. [Also his targets looked like he was shooting a varmit rifle] Lee