RE: 308, 270, etc?
If your primary game is anything up to and including deer sized game, I would highly suggest a 25-06. If your considering bigger game, then I would up the caliber size a bit. Of course, with a decent shooter and a decent bullet...the 25-06 should be capable of taking elk. Like the 300 WM, the 25-06 is one of those magic calibers that shoots far better than it should.