just this past hunting season we took 3 deer with a 243 none of them took 1 shot after being shot. one was neck shot that droped the other was a sholder lungs droped then the other was heart shot. Its a great deer caliber. all were shot using 100gr serria gamekings. this was from two sperate rifles and hunters. shots were from 125 to 175 yards on big alberta mulies.