LOTS OF VARIABLES THERE!! How close? What load? How many ftlbs of energy? What shot angle? You have a high powered rifle not a nuclear device. Close doesn't get it and only counts in hand grenades, horshoes, and global thermonuclear devices. What scares me about some people with magnum loads is they often have more weapon than they can accurately shoot. If you hit him in the eye a 22 rimfire will get it done.

Having said that the old timer that taught me to hunt said to think of the kill zone as about the size of your dinner plate. Its a safe rule. Will he die if you hit him somewhere else? Most likely. I have seen deer shot in the head, neck, lungs, the spine, the ass, the gut. Every shot was fatal. If you like chasing him through the woods hit him most anywhere. A lot of shots will kill him eventually but you may or may not find the animal.