Sharp shooter asked:

Could I use a 460gr Buffalo Bullet on Elk and deer and a 310gr ballet on antelope keeping the sight the same?

Yes, but each will have different ballistics. If your muzzle-velocities are the same (which requires different charges for each projectile), then there will be little difference until you get further out. You may be surprised to hear that, given the same initial muzzle velocity, the 460 will out perform the 310 having a zero more distant (owing to its better ballistics). In my way of thinking, this is the best way to have the same sighting for two different loads. Even so, the 460 will perform better for all your prey, in distance, trajectory, and KE at range. The only benefits of the 310 being less powder use andless recoil.

You have the option of using more powder with the 310. If you do, you will find that your zero with the 310 is more distant than with the 460 and that you are going to be higher with this round than line of sight at distances that the 460 is dropping sharply. This is a very difficult way to shoot a weapon.

Trying not to beat a dead horse, you may consider just using the 460 or 535. In the end, I think you will be more satisfied, that is if, you wish to keep your sights in one place all season.

Do you think the 310gr Ballet is enough for large deer and elk? I would like to use a 535gr No Excuses on elk. Is it too much for the large muleys though?

If I owned a .54 like you. I would hope that the 535 shot well in it. That is what I would use for elk and anything else. The exception would be if I were trying to develop a load which would give me greater range. In which case, I would be wanting alighter bullet with a ballistics coefficient approaching or exceeding that of the 535. Something like a precision semi-spitzer or spitzer point.

My 2 cents.

Happy Hunting, Phil