Chazy, the Crimson Trace sights are adjustable with tiny allen screws.
Most of the other ones I've seen are done that way too.

Laser sights are a great tool to diagnose trigger control problems.
Your wife should see a huge improvement if she uses it during dry fire practice.
Just remember to use some kind of snap cap or spent shell casing for the 22, so she doesn't crack the tip off the firing pin.
Dry firingis rough on those rimfires.