RE: 22-250 vs 7mm-08
heck this wasn't in the question but if you want a gun you can get ammo for "anywhere" then heck get an 06 and be done with it, Now I reload and there is a Wal mart local that carries 7mm08 so to me it's not an issue, also you can go into your "local Walmart" and they will order just about anything you want, or at least the couple around here will (you got to stand around forever for the sporting goods manager) a 270 also is in that "you can get ammo anywhere" deal, but between the 2 choices if it was me I would go with the 7mm08