Lanse,
I'm a very big fan of the 25-06 been using one for years,you have to very picky with it when it comes to elk.It will work and work well with good bullet placement.I gave one to my nephew 2 years ago(Ruger #1) along with 3 boxes of handloaded 115 barnes-x bullets with the advice,use only for elk.He shot a cow this year at 235 something yards,one shot through the lungs.But on the other hand I lost a bull a few years back,my fault.Picked a bad shot and took it(Don't need anymore Manboy aruments here).So it's a crap shoot on a all around varmit,deer,antelope,elk,bear,moose gun.If I had to pick just one I would take a 30-06 it works all the way around from 55 gr-to-220 RN.
But why have just one,buy the 25-06 enjoy the piss out of it and if and when the time comes buy another rifle.

Now Jeff no offense here but one quote you are a .270 fan and 'It should fit the bill" then your a 300 winne fan come on stick with oneflavor of Ice cream here.
Just kidden around.
Any thing from 280 rem to 458 win mag will work,just find one that fits.I use alot of uper end 300,338 and .35 cal magnums for most of my elk hunting.But I have alot of others in between for gophers to Elephant.
BBJ