RE: Which Gun to drop them down??
I shot a doe at about 30 yards with a 180 grain .30-06 this year. There was a half-dollar size hole on BOTH sides of the rib cage, looking into the body cavity when I field dressed this deer. When I picked the deer caracass up to shift it to a more favorable position for field dressing, there was a loud audible bellows sound from the side of the doe. Also, blood poured out of one of the holes in the deer like from a spigot. That was one dead deer. Nevertheless, this deer was able to run about 20 yards. How did this happen given this formidable damage? One of the front shoulders was also broken.
Don't count on any round planting a deer on the spot. Any hit with any reasonable cartridge may still result in the deer running 50 yards.