Im only asking about Deer on this Post.

"What I mean by picked shot is there are limits to where you can shoot a critter with your chosen rifle/caliber/bullet combination."

I think any bullet combo will penetrate from infront of the rear hind quarter threw to the front quarter on a Deer. I dont think its ok to put a certain shot on them from one bullet but not the other. I dont think shooting a deer in the ass with any combo is ethical(I know you didnt state it was). Bad shot placement is bad shot placement. I dont think it makes a difference what bullet you have.

My point is, that if we were out hunting and I handed you a rifle to shoot a deer, would not knowing whatcaliber/bullet you had(assuming a deer rifle,deer at100 yards distance not an issue) change where your aim point was. I honestly dont thinkit would make a difference making an ethical shot.