I use the .243., 6.5mmSwede, 7mm-08 and the .270, it all depends on what I want to take on that day. I also have many, many calibers in the safe!
I have posted the elk and mulie I shot within 3hrs with the .270/ 150gr NP and the moose I shot with the 6.5mmSwede /156gr Norma "Alaska" It works for me!
I normally use the 130gr NPin the .270 and 140gr SuperX-SPin the 6.5mmSwede, 150gr PH in the7mm-08 and 95gr Fusion in the .243.