I've got a Marlin .17 with a bull barrel and very nice Nikkon scope. I've knocked a crow out of a tree top at about 230 yards withit. So, under the right conditions, one should be able toscore head shots on coyotes at that distance. My concern would be whether the bullet would have enough juice to penetrate the skull at that range. As for body shots, I would be leery about trying anything over the 100-120 yard range unless you are an excellent tracker.