Try 110 grs. of pyrodex select and a 225 power belt HP.Shot very well for me last year,took one deer at 155 yds dropped in its tracks. You can see a group I shot using this by clicking on the link below,one is with the Knight 45 disk and 2 are with the Encore 50 cal

http://www.hunting-pictures.com/memb...ght&encore.jpg