Here is an interesting article by Chuck Hawks on accuracy and hunting rifles.
http://www.chuckhawks.com/practical_accuracy.htm
I would tend to agree with him. While having an ultra accurate rifle is sure nice, it isn't worth pulling your hair out when hunting large game at medium distances.
Usable sights and the best bullet for the job is more important to me.
I strive for 2 inch groups or better at 100 yards though, just because I am anal and do more target shooting than hunting with most of my guns.
However the current load I am using in my slug gun only gets 4 inch groups or so and I didn't have any trouble putting the slug where I wanted it this year. I felt the 600 grn slug was worth the trade off.
Paul