What do you want to hunt with it? Those are two completely different cartridges. One is medium to big game and the other is a varmint round.

If you are going for long range accuracy I don't think you can beat the 308 to be honest.

Two other rounds I would consider would be the .223 and the .243. Both are fairly flat shooting accurate rounds. The .243 would work on either deer or varmints pretty well to boot. The .223 would be cheaper to shoot. I 22-250 is basically a hopped up .223 from what I understand.

I wouldn't rule out the .270 either.

Paul