I have shot deer with a .243, .270, 30.06, 308 Norma Mag, .338 Win mag loaded down and 44 mag pistol they all have there vurtues. If we are talking 300 plus yards on a consistant basis then a magnum is the way to go if you have an 3006 then i recommend a .338 becuase .300 doesn't give you much of an edge over the 06'. I don't care for the 7MM'sbut some folks swear by them my opion is if i were to buy a magnum for all it would be a .338 or .375 H & H. The .338 has better bullet selection and better ballistics than the .375 but if grizzlies are on your plate I want more thump. if we are talking deer, elk moose,caribou the .338 is plenty.

For standard standard calibers .308, .270, .280 and 06 with the 3006 obviouslly being the most versital. I like the .270 on deer it's vicsious when placed correctly on the shoulder alomost too much meat loss. The .243 is a little light by my experience you often have to chase them some when hit. The .280 is a good balance or 7mm-08 is a great choice with moderate recoil.