I say stay with 100. What you'll gain you'll lose sort a speak. I went to 150 gr and lost a lot of accuracy. As far as 100 gr of powder and knock down (I use 240Gr XTP's). I shot a doe at 134 Yards Saturday night (she wasn't small weighed in at 112 lbs caped out). Double lunged her, she jumped 5 feet in the air, took a step and feel on her nose...freezer is full now. I have seen a lot of animals fall to 100 gr and 180-240gr XTP's, so you have plenty of power. In other words stick with what you know and practiced, no sub for good accuracy and shot placement IMO.