It's possible, though I don't think it will change all that much at 50 yds, but at 100, it could change quite a bit. 50 grains is a lot of change in added powder. I'd stick with what you practiced with until you have time to practice with 150 grains. If you're concerned about not having enough power, rest assured that a 50 cal with 100 grains has all the knockdown power you'd need at 100 yds fir deer sized game. I've taken plenty with even 90 grains in my older smoke poles.