RE: We speak of long range in here so.....
I regularly shoot my .50 BMG and .300 Mag at 600 and 1000 yards using a 9" steel gong at 600 and a 12 at 1000.
With that being said, MOST people have no idea how much a bullet can drop. Even at 300 yards. At 600 yards with just a little breeze, its enough to drift your shot right off of the target.
The great thing about a Mildot scope is the ability to range targets and the ability to use each dot as a aim point at various ranges.
Even so...it takes lots of practice. The deer hunter that shoots just a shot or two before the season to verify his zero wont be able to hit a deer much past 300 yards.