With the powders and bullets available today, the .45 will out-perform the .50 as a long-range rifle, particularly if you are a sabot user. I am not, so I continue to use my "out-performed" .50's!! But the new .45's will give higher velocities and flatter trajectories than the .50's. I recommend you go to http://www.huntamerica.com and ask Rattus about this matter!!

Keep yore powder dry!!