IMHO the .204 is the way to go. . . you'll hear all sorts of horror stories with any caliber and any animal. . .

i've been shooting a .204 for quite some time and there's nothing like shooting a coyote in the eye from 200yds or busting a crow at 350yds. personally, i don't shoot much over 200yds on account of where i hunt a 200yd is near limits. . . but i have some friends near columbus, ohio who have a 500 yd shot and have killed coyotes with their CZ 204 at 400yds !!

its all about shot placement and ammo. they were using 40 gr hornaday's with hand loads.

the 22-250 is also a good caliber. . . .but the horror story i'll tell ya is of the day my columbus friend shot a coyote 3 times at 200yd with his reminton 22-250 and the dog still ran off. . . . my 204 will drop a coyote in one shot withing 300yds and he MIGHT run 5 yds. . . if i hit a rib.

but when i hunt the coyote i take my 1911A1 .45 for those close shots

try a 204 and see wat ya think
www.savagearms.com/12fvsingleshot.htm