22-250 + 55-grain Nosler Ballistic Tips = Dead dogs out to 400-yards. Never underestimate the coyote's will to live. If you want bang-flop performance, the 22-250 is hard to beat. IMO, the .204 does not have the nuts to take tuff coyotes at longer ranges. Field reports prove this out. The .204 is a fun caliber but the 22-250 is all business and kills them NOW.