IMHO any cal. mentioned here would kill a deer if shot placement was right at 200 yrds but IMHO70% of the people on this topic could place a shot right at 200 yrds and maybe 30% at 300 yrds and I am not one of them so I don't try it. Out past 200 yrds? Not me, Iwould stock him and get much closer fora muchbetter quality shot! It's all in what cal. you like and feel comfortable with. Just my .02 worth