36-37 grains of Varget with 50 V-Maxes is my favorite .22/250 load, depending on the rifle. It's accurate and fast, and splatters PDs like they ate some C-4.
Max loads of Varget with 40sare also very fast, but aren't too good for long distance
With 55 grain V-Maxes, I used a lot of H-4895, H414 and H380, the 4895 gave better velocities than the ball powders (3750 compared to 3550, in a 26" Winchester), but got about the same accuracy.
I haven't owned a .41 for several years (since Lil Gun came out) but I liked a home cast Lyman 410459 cast bullet (225 actual weight) with 11.0 of the older Unique, for 1365 and tiny groups. Sorry I can't be more specific for your needs, but these might give you a good start to someplace.....