I have used 150gr Core Lokts out of my 300 winny, at whitetail deer, and they made a mess of the lungs and heart!!!! I really dont think you need a premium bullet for deer, like you do for elk and larger game. A good soft tip bullet will do just fine. I have shot deer that have run for 25 yds, and when we open them up, there is no heart or lungs!!! I dont think a 50 cal would have stoopped dear when they rn like that, and dont know their dead!!!!