Used correctly, the 22-250 or 220 Swift are impressive one-shot killers on deer. Used incorrectly they are one of the ugliest things you have ever seen. Just like most things in life I suppose. One of P.O Ackleys books had a section on the subject and the info was very good. May have been Wilcats of the World, or something like that, it is a two volume set. He even used the .228 Ackley to flat lay down some elk.

I haven't shot many deer with my swift, but I've never hit them twice and never had them go more than 30 yards, and that was with (god forbid) a 55 grn ballistic tip. The 53 barnes shoots horrible in my 40 XBKS, about the only bullet I have ever tried that it wouldn't shoot. That and the 70 grn speer...

I guess the problem for me is what if it comes down to that 250 yard quartering shot on ole mossy horns. I don't feel comfortable with a 22 in that situation. You can take an iffy shot or pass. With my 30-06, 165 interbond I don't worry about it. Both my boys learned to shoot deer with my 7 x 57, and there were sure times I was glad of that heavier bullet.