Whatever shoots the best out of your gun for sure. However, if you live in the south and hunt smaller bodied deer look more into the rapid expansion bullets, i.e ballistic tip, sst, gameking or plain jane core lokts in anywhere from 150-180 grain.Stayaway from30 caliber 125 grainbullets because they are intended for varmints.If you live in an area with larger bodied deer look into some of the tougher construced bonded bullets such as the accubond or interbond. Ive shot a few texas deer with the 180 accubond and while it did the job, it did not do quite as much damage as I had hoped but it designedmore for heavy game or large bodied deer.Personally I am shooting 165 grain Hornady SST's in my 30-06 because they are gettin about an inch at a hundred yards, but I have yet to try them on deer. Good Luck with your choice, but again shoot what shoots the best from your gun.