Gene...I am surprised when a deer doesn't drop in its tracks, at least 75% of the deer I shoot drop...Either a high lung shot or a high shoulder shot (bullet through the shoulder blade) will drop them...angling away from you...put the bullet into the off shoulder blade...angling toward you...where the neck joins the shoulder...any of these shots with a good bullet will drop them...

I sight in about 2 1/2 high at 100 yards...and in the 100-150 yard range I will hit about 2-3 inches above dead center of the deer....or about 2-3 inches below the spine...I think that is the key...if your bullet hits the lungs dead center...they will run a few yards...usually no problem...except in eastern NC it seems most of out fields have swamps or cutovers around them...I'd rather drop them in the field than have to wade into the swamp to get them out...

Also...you don't need a cannon to do this...I have used a .243 for over 25 years...